Therapeutic drug monitoring of amikacin in septic patients

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Therapeutic drug monitoring of amikacin in septic patients

INTRODUCTION Use of higher than standard doses of amikacin (AMK) has been proposed during sepsis, especially to treat less susceptible bacterial strains. However, few data are available on drug concentrations during prolonged therapy and on potential adverse events related to this strategy. METHODS Sixty-three critically ill patients who required AMK administration for the treatment of severe...

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Therapeutic drug monitoring of amikacin in preterm and term infants.

INTRODUCTION Amikacin is a commonly-prescribed drug used for the empirical treatment of bacterial infections in neonates. A marked change in the pharmacokinetics of amikacin has been reported during neonatal life. Amikacin has a very narrow therapeutic range and can cause very serious side effects such as nephrotoxicity and ototoxicity. The current therapeutic dose of amikacin, i.e. 15 mg/kg of...

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Therapeutic Drug Monitoring of Sirolimus,Correlation With Laboratory Parameters In Transplant Patients

Sirolimus is a potent immunosuppressive agent administered as prophylactic agent to prevent rejection after organ transplantation. Sirolimus must be used within a narrow therapeutic window. Due to inter- and intra-variability, sirolimus blood concentrations may be affected, therefore, there is no possibility of predicting the sirolimus blood concentrations based on the dose patients received. T...

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Therapeutic Drug Monitoring of Valproic Acid in Patients with Monotherapy at Steady State

Objective(s) The role of therapeutic drug monitoring (TDM) in patient care has grown rapidly since its introduction three decades ago. The aim of present study was to evaluate the possible relationship between serum levels and the clinical response of valproic acid (VPA). Materials and Methods In the present study we evaluated a homogeneous group of adult patients receiving VPA monotherapy. ...

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ژورنال

عنوان ژورنال: Critical Care

سال: 2013

ISSN: 1364-8535

DOI: 10.1186/cc12844